Diabetes: Phenotyping and etiologies

This program is dedicated to developing of a common phenotyping grid between pediatrics and adult diabetology, and to centralizing the phenotyping of circulating immune cells for an optimized use of data by clinical research units.

Subclassification of individuals with adult-onset diabetes. Individuals who would traditionally be classified as having T1D, LADA or T2D were subgrouped using a data-driven approach based on six commonly measured variables known to reflect central disease mechanisms. Individuals with known monogenic or secondary diabetes were excluded since they already have a well-defined diabetes type. The resulting subtypes could allow clinical support, with better prediction of risk of complications and response to therapy, and improved power and specificity in scientific endeavors by enabling studies in more homogeneous patient groups.

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© Society for Endocrinology 2021

Teams involved in this program

 

 

Team members

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Diabetes Institute scientific day

Diabetes Institute scientific day

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The overall goal of this Diabetes Institute scientific day is to provide the most important and up-to-date research in the field of metabolism made at University Paris Cité. The workshop will focus on understanding the recent progress in adipose tissue and liver biology including metabolic and inflammatory processes in the control of the energy homeostasis. Special emphasis will be done to highlight the importance of the organ crosstalk and how signaling pathways in one tissue could affect the metabolism in other tissue.