Immunity and Metabolism of Diabetes

Objectives

IMMEDIAB wants to establish a comprehensive understanding of the transcriptomic and epigenomic pathways that control monocyte and macrophage function and of the epigenetic enzymes involved in monocyte and macrophage differentiation and activation.

Future Directions

Our key challenges in the upcoming years will be to study epigenetic changes in human diabetes and to better understand how epigenetic pathways control the inflammatory repertoire in diabetic complications.

Publications

• Orliaguet L., Ejlalmanesh T., Humbert A., Ballaire R., Diedisheim M., Julla J-B., Chokr D., Cuenco J., Michieletto J., Charbit J., Lindén D., Boucher J., Potier C., Hamimi A., Lemoine S., Blugeon C., Legoix P., Lameiras S., Baudrin L.G., Baulande S., Soprani A., Castelli F.A., Fenaille F., Riveline J-P., Dalmas E., Rieusset J., Gautier J-F., Venteclef N., Alzaid F. (2022). Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling. Nat Commun. Aug 30;13(1):5089. doi: 10.1038/s41467-022-32813-z.
• Potier L., Mohammedi K., Saulnier P-J., Fumeron F., Halimi J-M., Venteclef N., Marre M., Hadjadj S., Roussel R., Velho G. (2022). Plasma Adrenomedullin, Allelic Variations in the ADM Gene, and Risk for Lower-Limb Amputation in People With Type 2 Diabetes. Diabetes Care. Jul 7;45(7):1631-1639. doi: 10.2337/dc21-2638.
• Julla J-B., Jacquemier P., Fagherazzi G., Vidal-Trecan T., Juddoo V., Jaziri A., Mersel H., Venteclef N., Roussel R., Massin P., Couturier A., Gautier J-F., Riveline J-P. (2021). Is the Consensual Threshold for Defining High Glucose Variability Implementable in Clinical Practice? Diabetes Care. Jul;44(7):1722-1725. doi: 10.2337/dc20-1847. Epub 2021 Jun 7.
• Alzaid F., Julla J-B., Diedisheim M., Potier C., Potier L., Velho G., Gaborit B., Manivet P., Germain S., Vidal-Trecan T., Roussel R., Riveline J-P., Dalmas E., Venteclef N., Gautier J-F. (2020). Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID-19 in type 2 diabetes. EMBO Mol Med. Oct 7;12(10):e13038. doi: 10.15252/emmm.202013038. Epub 2020 Sep 11
• Drareni K., Ballaire R., Alzaid F., Goncalves A., Chollet C., Barilla S., Nguewa J-L., Dias K., Lemoine S., Riveline J-P., Roussel R., Dalmas E., Velho G., Treuter E., Gautier J-F., Venteclef N. (2020). Adipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin Secretion. Cell Rep. Sep 15;32(11):108141. doi: 10.1016/j.celrep.2020.108141.