Diabetes: Phenotyping and etiologies
This program is dedicated to developing of a common phenotyping grid between pediatrics and adult diabetology, and to centralizing the phenotyping of circulating immune cells for an optimized use of data by clinical research units.
Subclassification of individuals with adult-onset diabetes. Individuals who would traditionally be classified as having T1D, LADA or T2D were subgrouped using a data-driven approach based on six commonly measured variables known to reflect central disease mechanisms. Individuals with known monogenic or secondary diabetes were excluded since they already have a well-defined diabetes type. The resulting subtypes could allow clinical support, with better prediction of risk of complications and response to therapy, and improved power and specificity in scientific endeavors by enabling studies in more homogeneous patient groups.
© Society for Endocrinology 2021
Teams involved in this program
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Immunity and Metabolism of Diabetes IMMEDIAB
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Immunology of Diabetes
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T-cell tolerance, biomarkers and therapies in type 1 diabetes
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