Nov 12, 2023 | Diabetes Institute, Functional pancreatic beta cell mass in rodent and human, Publications, Research, T-cell tolerance, biomarkers and therapies in type 1 diabetes
A collaborative work between the teams of R Mallone and R Scharfmann leaded by L Rachdi indicate that TRP could induce immune tolerance to β cells by promoting their immune evasion through HLA-I downregulation and PD-L1 upregulation.
Apr 20, 2023 | Diabetes Institute, Publications, T-cell tolerance, biomarkers and therapies in type 1 diabetes
A perplexing feature of type 1 diabetes (T1D) is that the immune system destroys pancreatic β-cells but not neighbouring α-cells, even though both β-cells and α-cells are dysfunctional. Dysfunction, however, progresses to death only for β-cells. Recent findings...
