Jun 26, 2023 | Diabetes Institute, Publications
Marc Foretz, Bruno Guigas & Benoit Viollet Proposed mechanisms for metformin-induced reductions in blood levels of glucose. © Nature Reviews Endocrinology Abstract Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in most...
Jun 17, 2023 | Central Control of Feeding Behaviour and Energy Expenditure, Diabetes Institute, METABOL’IC Platform for the analysis of metabolism from the cell to the small animal, Publications
An article by Anne-Sophie Delbès, Mar Quiñones, CédricGobet, JulienCastel, Raphaël G. P. Denis, JérémyBerthelet, Benjamin D. Weger, Etienne Challet, Aline Charpagne, Sylviane Metairon, Julie Piccand, Marine Kraus, Bettina H. Rohde, John Bial Elizabeth M. Wilson,...
May 20, 2023 | Diabetes Institute, Insulin signaling, glucose sensing and glucotoxicity, Publications
Abstract Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). Hepatic metabolism of carbohydrates into...
Apr 20, 2023 | Diabetes Institute, Publications, T-cell tolerance, biomarkers and therapies in type 1 diabetes
A perplexing feature of type 1 diabetes (T1D) is that the immune system destroys pancreatic β-cells but not neighbouring α-cells, even though both β-cells and α-cells are dysfunctional. Dysfunction, however, progresses to death only for β-cells. Recent findings...
Apr 20, 2023 | Diabetes Institute, Publications, Regulation of Glycemia by Central Nervous System
Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice Abstract Innate immune mediators of pathogen clearance, including the secreted C-type lectins REG3 of the antimicrobial peptide (AMP) family, are known to be...
Mar 17, 2023 | Diabetes Institute, Immunity and Metabolism of Diabetes, Publications
Inflammatory and immune etiology of type 2 diabetes By Camille Blériot, Élise Dalmas, Florent Ginhoux , Nicolas Venteclef Trends in Immunology Highlights A specific type 2 diabetes (T2D) patient endotype, termed ‘severe insulin resistant’, is characterized...
