Dec 21, 2023 | Diabetes Institute, From inflammation to cancer in digestive diseases, Publications
This article discusses the origin of pancreatic lesions associated with pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) is currently the fourth leading cause of cancer death worldwide. It is projected to become the second leading cause of cancer death by...
Nov 12, 2023 | Diabetes Institute, Functional Pharmacology and Pathophysiology of Membrane Receptors, Publications, Research
This study, from Ralf Jockers and Julie Dam’s team as part of a European network for the prevention of childhood obesity, OBELISK,defines impaired GLP1R cell surface expression as a risk factor for traits associated with type 2 diabetes and obesity and provides...
Nov 12, 2023 | Diabetes Institute, Functional pancreatic beta cell mass in rodent and human, Publications, Research, T-cell tolerance, biomarkers and therapies in type 1 diabetes
A collaborative work between the teams of R Mallone and R Scharfmann leaded by L Rachdi indicate that TRP could induce immune tolerance to β cells by promoting their immune evasion through HLA-I downregulation and PD-L1 upregulation.
Nov 12, 2023 | Diabetes Institute, Publications, Regulation of Glycemia by Central Nervous System, Research
Christophe Magnan and Céline Cruciani-Guglielmacci in collaboration with the team of Xavier Fioramonti highlight a new neuronal network involved in the regulation of the counter-regulatory response In particular, this study shows that DR 5-HT neurons detect...
Nov 12, 2023 | Immunity and Metabolism of Diabetes, Publications, Research
Here, we propose that a significant proportion of individuals may harbor an immune profile that renders them susceptible to developing T2D. We note the heterogeneity of circulating monocytes and tissue macrophages in organs that are key to metabolic disorders such as...
Jul 5, 2023 | Diabetes Institute, Publications, Regulation of Glycemia by Central Nervous System
Mireia Montaner, Jessica Denom, Wanqing Jiang, Christophe Magnan, Stefan Trapp, Hirac Gurden A. Schematic illustration of viral delivery in the OB and subsequent protocol performed to assess odor-induced CPIR in PPG-shRNA RD mice. Yellow circle represents peanut...
