Molecular basis of several congenital or neonatal endocrine disorders and establishment of new therapeutic strategies
PI: Michel POLAK
Our goal is to study some rare forms of congenital disorders of the endocrine pancreas.
In the last fifteen years, we have focused our research on some specific forms of neonatal diabetes in Human. We have been able to define innovative treatments for children with neonatal diabetes, a rare genetic form of dysfunction of the insulin-secreting cell.
During those years we have gained a considerable experience in the study of the molecular control of the islet cell development and we have also been able to establish a network with clinicians from France, Europe and several other countries in particular from Maghreb and Middle east; through this collaboration a depository of rare disorders of the endocrine pancreas has been established with a precise description of cases and DNA from index cases. This is a very helpful biological resource to continue our work.
Our team intends to pursue this « translational » research through further clinical trials, in link with our pediatric endocrinology and diabetology department at Necker Enfants Malades hospital and the clinical investigation center within Institut Imagine. We believe that, through the discovery of new molecular anomalies of endocrine pancreas development we will :
- better understand some aspects of the development of those glands
- discover some anomalies, which are observed much more frequently in adults in an heterozygote state
Read more
A new article from Cécile Haumaitre and collaborators discusses the origin of pancreatic lesions associated with pancreatic cancer
Pancreatic ductal adenocarcinoma is currently the fourth leading cause of cancer death worldwide. It is projected to become the second leading cause of cancer death by 2030. Unfortunately, PDAC is often diagnosed at an advanced stage, resulting in a 5-year survival rate of less than 10%. Since the most common precancerous lesions of PDAC are currently not clinically detectable, understanding the mechanisms that lead to their formation and progression is crucial to enabling early diagnosis and more effective therapeutic intervention.
Congrès de la SFD 2024
Tarifs préférentiels jusqu’au 31 janvier 2024. Retrouvez toutes les informations du congrès
Journée Thématique SFD
la Journée Thématique de la SFD aura lieu cette année le 15 décembre 2023 à l’Institut Pasteur de Paris, et sera consacrée au sujet «Diabète, îlots et Insulino-Sécrétion».
Journée Scientifique conjointe Institut du Diabète et Graduate School METOD
Keynotes of Stefan Trapp (University College London) and Marc Donath (University of Basel)