Physiopathology of ocular diseases – therapeutic innovations

Whatever the primitive cause of disease, vision is lost through major common mechanisms leading to the loss of tissues transparency, death of visual cells and abnormal tissue reactions such as inflammation, fibrosis, and neovascularization.
Our team’s objectives are to identify key regulatory molecular targets involved in the pathogenesis of major mechanisms responsible for vision loss, accessible to modulation by drugs, administered locally, and applicable to diseases of various origins. Driven by unmet medical needs and innovation, we develop translational research.
The scientific questions underlying our work emerge from clinical problems. We also analyze the mechanisms of action of drugs commonly used in ophthalmology (i.e. anti-VEGF and corticoids), as well as the ocular risks of exposure to environmental burdens (i.e. light exposure).
The research performed by our team fulfills the gap between discovery and proof of concept in man. Valorization is considered for allowing further developments of the research conducted in the team.
The main mechanisms responsible for vision loss in ocular diseases are loss of transparency, fibroglial and neovascular proliferations and cell death. We study several regulatory pathways to control these vision threatening features.