May 20, 2023 | Diabetes Institute, Insulin signaling, glucose sensing and glucotoxicity, Publications
Abstract Excessive sugar consumption and defective glucose sensing by hepatocytes contribute to the development of metabolic diseases including type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD). Hepatic metabolism of carbohydrates into...
Jan 31, 2023 | Diabetes Institute, Insulin signaling, glucose sensing and glucotoxicity, Publications, Research
Objective: A common feature of metabolic diseases is their association with chronic low-grade inflammation. While enhanced gut permeability and systemic bacterial endotoxin translocation have been suggested as key players of this metaflammation, the mechanistic bases...
