Apr 20, 2023 | Diabetes Institute, Publications, Regulation of Glycemia by Central Nervous System
Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice Abstract Innate immune mediators of pathogen clearance, including the secreted C-type lectins REG3 of the antimicrobial peptide (AMP) family, are known to be...
Mar 17, 2023 | Diabetes Institute, Immunity and Metabolism of Diabetes, Publications
Inflammatory and immune etiology of type 2 diabetes By Camille Blériot, Élise Dalmas, Florent Ginhoux , Nicolas Venteclef Trends in Immunology Highlights A specific type 2 diabetes (T2D) patient endotype, termed ‘severe insulin resistant’, is characterized...
Jan 31, 2023 | Diabetes Institute, Insulin signaling, glucose sensing and glucotoxicity, Publications, Research
Objective: A common feature of metabolic diseases is their association with chronic low-grade inflammation. While enhanced gut permeability and systemic bacterial endotoxin translocation have been suggested as key players of this metaflammation, the mechanistic bases...
Dec 20, 2022 | Biology and pathology of the endocrine pancreas, Diabetes Institute, Publications
Diabetes Mellitus is a metabolic disorder characterized by a chronic hyperglycemia due to an impaired insulin secretion and a decreased in peripheral insulin sensitivity. This disease is a major public health problem due to it sharp prevalence. Therefore, it is...
