I am interested in genetics and immunology of type 1 diabetes and type 2 diabetes. We are currently studying a) the role of MAIT cells in obesity and type 2 diabetes and b) the role of the circadian gene BMAL2 and its implication in the regulation of the immune system.
Main Publications
Gut mucosa alterations and loss of segmented filamentous bacteria in type 1 diabetes are associated with inflammation rather than hyperglycaemia.
Rouland M, Beaudoin L, Rouxel O, Bertrand L, Cagninacci L, Saffarian A, Pedron T, Gueddouri D, Guilmeau S, Burnol AF, Rachdi L, Tazi A, Mouriès J, Rescigno M, Vergnolle N, Sansonetti P, Christine Rogner U, Lehuen A. Gut. 2022 Feb;71(2):296-308. doi: 10.1136/gutjnl-2020-323664. Epub 2021 Feb 16. PMID: 33593807
The Spontaneous Autoimmune Neuromyopathy in ICOSL-/- NOD Mice Is CD4+ T-Cell and Interferon-γ Dependent.
Briet C, Bourdenet G, Rogner UC, Becourt C, Tardivel I, Drouot L, Arnoult C, do Rego JC, Prevot N, Massaad C, Boyer O, Boitard C. Front Immunol. 2017 Mar 31;8:287. doi: 10.3389/fimmu.2017.00287. eCollection 2017. PMID: 28424681
The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis.
Lebailly B, Langa F, Boitard C, Avner P, Rogner UC. Mamm Genome. 2017 Feb;28(1-2):1-12. doi: 10.1007/s00335-016-9665-4. Epub 2016 Sep 26.
Keywords
diabetes obesity circadian genetics