Our team combines researchers, physicians and surgeons. It is internationally recognized for its expertise in gut physiology and pathology.
Since 2012, we focused on intestinal adaptations either in the context of over- or under-nutrition, more specifically we deciphered mechanisms of gastrointestinal adaptations in response to weight-loss surgical therapies (bariatric surgeries) and massive intestinal resection, main cause of intestinal failure (short bowel syndrome).
I focus on intestinal adaptation in response to bariatric surgery in strong association with two digestive surgery units (Bichat & L Mourier hospitals), European leaders in bariatric surgeries. Together we developed animal models of bariatric surgery; Sleeve, Roux-en-Y Gastric Bypass (RYGB) and One Anastomosis Gastric Bypass (OAGB) and characterized the impact of bariatric surgery on intestinal remodeling focusing on nutrient transport and metabolism. Combining experimental research in these preclinical models with clinical studies, we identified differences in alimentary glucose absorption and intestinal blood glucose handling after RYGB versus Sleeve (Gastroenterology, 2016). We also characterized the protein malabsorption and oesophagus reflux after the controversial OAGB (AJP Gastrointest Liver Physiol. 2016, Obes. Surg. 2017, AJP Gastrointest Liver Physiol. 2019)
Main Publications
Cavin JB Couvelard ALebtahi R Ducroc R Arapis K Voitellier E Cluzeaud F Gillard L Hourseau M Mikail N Ribeiro-Parenti L Kapel N Marmuse J-P Bado A Le Gall M. Differences in Alimentary Glucose Absorption and Intestinal Disposal of Blood Glucose After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy. Gastroenterology. 2016 Feb;150(2):454-64
Jarry AC Merah N Cisse F Cayetanot F Fiamma MN Willemetz A Gueddouri D Barka B Valet P Guilmeau S Bado A Le Beyec Le Bihan J Bodineau L Le Gall M Neuromedin U is a gut peptide that alters oral glucose tolerance by delaying gastric emptying via direct contraction of the pylorus and vagal-dependent mechanisms. FASEB J. 2019 Apr;33(4):5377-5388
Siebert M Ribeiro-Parenti L Nguyen N.D. Hourseau M Duchêne B Humbert L Jonckheere N Nuel G Chevallier J-M Duboc H Rainteau D Msika S Kapel N Couvelard A Bado A Le Gall M Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model Scientific Reports 2020 Apr 30;10(1):7393
Ribeiro-Parenti L Jarry A-C Cavin J-B Willemetz A Le Beyec Le Bihan J Sannier A Benadda S Pelletier A-L Hourseau M Léger T Morlet B Couvelard A Anini Y Msika S Marmuse J-P Ledoux S Le Gall M Bado A Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells Nature Communications 2021 Jan 4;12(1):110
Keywords
gut hormones, bariatric surgeries, glucose homeostasis
Social media
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