The research theme of the team is focused on the study of the neural control of energy balance and more precisely of glycemia and food intake in preclinical models of obesity and type 2 diabetes.
We are interested in peripheral signals (metabolic and endocrine) that converge to the brain (mainly olfactory bulb and hypothalamus) and inform the organism of the energetic and nutritional status.
Our signal molecules of interest are mainly lipids (fatty acids, triglycerides and sphingolipids) and incretins.
We are also developing a theme focused on the study of peptides and microbial metabolites produced by the intestinal microbiota in the control of glycemia and food intake.
Main Publications
Gonzalez P, Dos Santos A, Darnaud M, Moniaux N, Rapoud D, Lacoste C, Nguyen TS, Moullé VS, Deshayes A, Amouyal G, Amouyal P, Bréchot C, Cruciani-Guglielmacci C, Andréelli F, Magnan C, Faivre J. Antimicrobial protein REG3A regulates glucose homeostasis and insulin resistance in obese diabetic mice. Commun Biol. 2023 Mar 15;6(1):269. doi: 10.1038/s42003-023-04616-5. PubMed PMID: 36918710
Sánchez-Archidona AR, Cruciani-Guglielmacci C, Roujeau C, Wigger L, Lallement J, Denom J, Barovic M, Kassis N, Mehl F, Weitz J, Distler M, Klose C, Simons K, Ibberson M, Solimena M, Magnan C, Thorens B. Plasma triacylglycerols are biomarkers of β-cell function in mice and humans. Mol Metab. 2021 Dec;54:101355. doi: 10.1016/j.molmet.2021.101355. Epub 2021 Oct 9. PubMed PMID: 34634522
Soleimanzad H, Montaner M, Ternier G, Lemitre M, Silvestre JS, Kassis N, Giacobini P, Magnan C, Pain F, Gurden H. Obesity in Midlife Hampers Resting and Sensory-Evoked Cerebral Blood Flow in Mice. Obesity (Silver Spring). 2021 Jan;29(1):150-158. doi: 10.1002/oby.23051. Epub 2020 Nov 10. PubMed PMID: 33174382.
Mortreux M, Foppen E, Denis RG, Montaner M, Kassis N, Denom J, Vincent M, Fumeron F, Kujawski-Lafourcade M, Andréelli F, Balkau B, Marre M, Roussel R, Magnan C, Gurden H, Migrenne-Li S. New roles for prokineticin 2 in feeding behavior, insulin resistance and type 2 diabetes: Studies in mice and humans. Mol Metab. 2019 Nov;29:182-196. doi: 10.1016/j.molmet.2019.08.016. Epub 2019 Aug 28. PubMed PMID: 31668389
Bellini L, Campana M, Rouch C, Chacinska M, Bugliani M, Meneyrol K, Hainault I, Lenoir V, Denom J, Véret J, Kassis N, Thorens B, Ibberson M, Marchetti P, Blachnio-Zabielska A, Cruciani-Guglielmacci C, Prip-Buus C, Magnan C, Le Stunff H. Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets. Diabetologia. 2018 Aug;61(8):1780-1793. doi: 10.1007/s00125-018-4629-8. Epub 2018 May 12. PubMed PMID: 29754287
Keywords
Hypothalamus, brain lipid sensing, insulin-resistance
Social Media
https://www.researchgate.net/profile/Christophe-Magnan