The aim of my research is to understand the mechanisms involved in the regulation of energy balance.
This requires knowledge of animal physiology, energy metabolism and its dysregulation and inter-organ communication.
My PhD at the University of Liverpool, followed by 5 post-doctoral fellowships have as a common thread the energy balance and metabolic diseases, mainly obesity and type 2 diabetes.
I have been a research engineer since 2012 and at the University of Paris Diderot and then the University of Paris Cité.
Presently, I work at the Cochin Institute to develop the Metabol’IC platform dedicated to Metabol’IC exploration from the cell to the animal.
Main publications
-Leuillier M, Duflot T, Ménoret S, Messaoudi H, Djerada Z, Groussard D, Denis RGP, Chevalier L, Karoui A, Panthu B, Thiébaut PA, Schmitz-Afonso I, Nobis S, Campart C, Henry T, Sautreuil C, Luquet SH, Beseme O, Féliu C, Peyret H, Nicol L, Henry JP, Renet S, Mulder P, Wan D, Tesson L, Heslan JM, Duché A, Jacques S, Ziegler F, Brunel V, Rautureau GJP, Monteil C, do Rego JL, do Rego JC, Afonso C, Hammock B, Madec AM, Pinet F, Richard V, Anegon I, Guignabert C, Morisseau C, Bellien J. CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury. J Adv Res. 2023 Jan;43:163-174. doi: 10.1016/j.jare.2022.03.004. Epub 2022 Mar 12. PMID: 36585106; PMCID: PMC9811321.
-Bakker W, Imbernon M, Salinas CG, Moro Chao DH, Hassouna R, Morel C, Martin C, Leger C, Denis RGP, Castel J, Peter A, Heni M, Maetzler W, Nielsen HS, Duquenne M, Schwaninger M, Lundh S, Johan Hogendorf WF, Gangarossa G, Secher A, Hecksher-Sørensen J, Pedersen TÅ, Prevot V, Luquet S. Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis. Cell Rep. 2022 Nov 22;41(8):111698. doi: 10.1016/j.celrep.2022.111698. PMID: 36417883; PMCID: PMC9715912.
-Cornejo MP, Denis RGP, García Romero G, Fernández G, Reynaldo M, Luquet S, Perello M. Ghrelin treatment induces rapid and delayed increments of food intake: a heuristic model to explain ghrelin’s orexigenic effects. Cell Mol Life Sci. 2021 Oct;78(19-20):6689-6708. doi: 10.1007/s00018-021-03937-0. Epub 2021 Sep 24. PMID: 34559253.
-Just PA, Charawi S, Denis RGP, Savall M, Traore M, Foretz M, Bastu S, Magassa S, Senni N, Sohier P, Wursmer M, Vasseur-Cognet M, Schmitt A, Le Gall M, Leduc M, Guillonneau F, De Bandt JP, Mayeux P, Romagnolo B, Luquet S, Bossard P, Perret C. Lkb1 suppresses amino acid-driven gluconeogenesis in the liver. Nat Commun. 2020 Nov 30;11(1):6127. doi: 10.1038/s41467-020-19490-6. Erratum in: Nat Commun. 2021 Mar 17;12(1):1831. PMID: 33257663; PMCID: PMC7705018.
-Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez-Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G. Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity. Cell Metab. 2019 Oct 1;30(4):754-767.e9. doi: 10.1016/j.cmet.2019.07.010. Epub 2019 Aug 15. Erratum in: Cell Metab. 2019 Dec 3;30(6):1171. PMID: 31422903.
-Péterfi Z, Farkas I, Denis RGP, Farkas E, Uchigashima M, Füzesi T, Watanabe M, Lechan RM, Liposits Z, Luquet S, Fekete C. Endocannabinoid and nitric oxide systems of the hypothalamic paraventricular nucleus mediate effects of NPY on energy expenditure. Mol Metab. 2018 Dec;18:120-133. doi: 10.1016/j.molmet.2018.08.007. Epub 2018 Sep 18. PMID: 30274714; PMCID: PMC6308028.
Keywords
Metabolism, DT2, physiology, nutrition, calorimetry
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