Theme: Genetics and genomics of autoimmune and inflammatory diseases
Methods: multifactorial genetics, integrative genetics, multiomics, biostatistics, bioinformatics
Main publications
Vandiedonck C (2018). Genetic association of molecular traits: a help to identify causative variants in complex diseases. Clinical Genetics, 2018 Mar, 93(3) :520-532.Review [doi: 10.1111/cge.13187; hal-03814278v1]
Onengut-Gumuscu S, Chen WM, Burren O, Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E, Bonnie JK, Szpak M, Schofield E, Achuthan P, Guo H, Fortune MD, Stevens H, Walker NM, Ward LD, Kundaje A, Kellis M, Daly MJ, Barrett JC, Cooper JD, Deloukas P; Type 1 Diabetes Genetics Consortium*, Todd JA, Wallace C, Concannon P, Rich SS. (2015) Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nature Genetics, 2015 April; 47 (4):381-386 *among the 426 collaborators.[doi:10.1038/ng.3245]
Vandiedonck C, Taylor MS, Lockstone HE, Plant K, Taylor JM, Durrant C, Broxholme J, Fairfax BP and Knight JC (2011) Pervasive haplotypic variation in the spliceo-transcriptome of the human MHC. Genome Research, 2011 Jul ; 21(7) :1042-54. [doi: 10.1101/gr.116681.110; hal-03814273v1]
Giraud M, Taubert R, Vandiedonck C, Ke X, Levi-Strauss M, Pagani F, Baralle FE, Eymard B, Tranchant C, Gajdos P, Vincent A, Willcox N, Beeson D, Kyewski B, Garchon HJ (2007) An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature, 448:934-937. [doi: 10.1038/nature06066]
Vandiedonck C, Beaurain G, Giraud M, Hue-Beauvais C, Eymard B, Tranchant C, Gajdos P, Dausset J, Garchon HJ (2004) Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasia. Proc Natl Acad Sci U S A, 101:15464-15469. [doi: 10.1073/pnas.0406756101]
Keywords
genetics, omics, T1D, autoimmunity, MHC
Social Media
https://orcid.org/0000-0002-6669-6923
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