I work on the effects of metformin on glucose homeostasis and enterohormone secretions after bariatric surgery in patients through a clinical study and in an experimental model which is the Goto-Kakizaki rats, a spontaneous type 2 diabetes model. I realise this project especially in female animals, who are made obese or not and operated on two types of bariatric surgery : the Roux en Y gastric bypass and the vertical sleeve gastrectomy, in order to treat them with metformin or not after the surgery. I hope understand the underlying mecanisms of bariatric surgery on type 2 diabetes remission but also the mecanisms of action of metformin on the intestine which plays a major role in the effects of metformin on type 2 diabetes.
Keywords :
Metformin, bariatric surgery, type 2 diabetes, enterohormones, intestine